Multiple genetic mutations and environmental causes have been linked to PD development, including mutations in GBA (encoding glucocerebrosidase, a mediator of autophagy), SNCA (encoding α-synuclein), LRRK2 (encoding leucine-rich repeat kinase 1, a mediator of autophagy), and PINK1 (a mediator of mitophagy), among others [77]. The gene discussed is GBA1; the disease is Parkinson disease.