Conversely, Chao et al. showed that EV-derived circSH3PXD2A inhibits the chemo-resistance and proliferation of SCLC in vitro and in vivo through the miR-375-3p/YAP1 axis, suggesting a role for this circRNA as a predictive biomarker for DDP-resistant SCLC patients [80]. Here, YAP1 is linked to small cell lung carcinoma.