NLRP6 and small cell lung carcinoma: The cross-talk between EVs and immunity in SCLC has been highlighted by Rao et al., who showed that the polarization of infiltrating macrophages (MØ) toward the M2 phenotype is mediated by tumor-derived exosomes via the NLRP6/NF-κB pathway, promoting SCLC metastasis in vitro and in vivo [84].