Recent studies suggest that cutaneous hemangiosarcoma likely originates from transformed mature endothelial origin, exhibiting a comparatively better biologic behavior with rare metastases, whereas other forms of HSA likely arise from the precursor (pluripotent) endothelial cell in the bone marrow, subsequently migrating and colonizing organs with viable microenvironments (spleen, liver, right atrium) [1,2,3]. This evidence concerns the gene ALB and angiosarcoma.