In the context of anti-tumor immunity, CD20 lymphocytes facilitate antibody-dependent cellular cytotoxicity (ADCC) and complement activation, as well as act as antigen-presenting cells (APCs), presenting tumor antigens to cytotoxic T lymphocytes [41,42].However, it has recently been demonstrated that B cells dampen the immune response through the production of immunosuppressive cytokines (IL-10, IL-35, TGF-β) in a way similar to Tregs [43]. Here, TGFB1 is linked to neoplasm.