Here, we evaluated the effect of CMA1 (nicotinamide riboside, L-serine, N-acetyl cysteine, L-carnitine tartrate) and CMA2 (nicotinamide, L-serine, N-acetyl cysteine, L-carnitine tartrate) as well as their individual components on the animal models of AD and PD. The gene discussed is CMA1; the disease is Alzheimer disease.