TGFB1 and liver disorder: It was shown that the GT haplotype, which carries the C-509T allele, associated with higher TGF-β1 production, is associated with the same liver disorder markers as elevated plasma TGF-β1 levels, suggesting a genetic basis for this relationship and indicating that increased TGF-β1 production caused by this genetic polymorphism may increase the risk of liver complications in obese patients.