TGFB1 and autoimmune hepatitis: In the case of impaired TGF-β signaling in transgenic mice with overexpression of a dominant-negative (inhibitory) TβRII receptor in T cells with induced AIH (immunized with syngeneic liver homogenate in adjuvant), there is increased leukocyte infiltration into the liver (mainly T cells), hepatocellular necrosis, increased IFN-γ production, and decreased IL-4 production, which in turn promotes a cellular response [31,32].