Therefore, the aim of the reported study was to comprehensively analyze the polymorphic variants of the VDR gene, i.e., rs 731236 (TaqI), rs1544410 (BsmI) and rs7975232 (ApaI), in menopausal women by searching for genetic markers to identify patients at a higher risk of developing osteoporosis in the context of their comorbidities. The gene discussed is VDR; the disease is osteoporosis.