According to the guidelines, basal insulin needs to be used in a patient with T2DM and severe hyperglycemia (generally blood glucose ≥ 300 mg/dL [≥16.7 mmol/L] or glycated hemoglobin [HbA1c] > 10%) or symptomatic hyperglycemia or if the patient has signs of catabolism (hypertriglyceridemia, weight loss or ketosis) [20]. Here, INS is linked to type 2 diabetes mellitus.