The recently published 5th Edition of the WHO Classification of Tumors of the Nervous System now mandates that IDH-wildtype diffuse and astrocytic glioma in adults are diagnosed as glioblastoma, even in the absence of histological high-grade features (microvascular proliferation or necrosis), when there is a TERT promoter mutation and/or EGFR gene amplification and/or chromosome 7 gain/chromosome 10 loss [4]. This evidence concerns the gene EGFR and glioblastoma.