Berzero et al. showed that IDH-WT gliomas with grade 2 histology (<2 mitoses per 10 high-power fields), meeting the definition for molecular glioblastoma, had substantially longer OS compared with IDH-WT grade 3 gliomas meeting the definition for molecular glioblastoma (median OS: 57 mo. The gene discussed is IDH1; the disease is glioblastoma.