On the other hand, concerning the diabetes-induced wound-healing abnormalities, the topical treatment with hemin also showed significant anti-inflammatory (e.g., reduction in TNF-α, IL-6, allied with the increase of IL-10) and antioxidant (e.g., increase in superoxide dismutase (SOD) and catalase, as well as the reduction in MDA and glutathione peroxidase) effects. This evidence concerns the gene TNF and diabetes mellitus.