The anti-inflammatory effect of hemin was already possible to observe with a relatively low dose, namely 75 μg/kg, administrated in an animal model of acute pancreatitis, represented by a significant reduction in pathological score in the liver and pancreas, as well as a reduced expression of a proinflammatory cytokine, namely tumor necrosis factor-α (TNF-α) [33]. This evidence concerns the gene TNF and acute pancreatitis.