PKM and ischemia: Because gene networking showed PPAR involvement in OGD/R, and considering also the results obtained in organoids with PKM2, and that is it known that PPARγ inhibits PKM2 in breast cancer and that the PPARα/γ agonist improves stroke outcome in mice, they hypothesized that therapeutic agents related to lipid metabolism, such as the PPAR agonist, may be effective against ischemia [83].