Indeed, Li-Feng Dong et al. demonstrated in the BC cell line MDA-MB-231 that this circRNA is involved in the stimulation of PD-L1 expression, hindering T-cells cytotoxic effect via the miR-622/CMTM6 axis [82], a crucial gene for suppression of PD-L1 ubiquitination and degradation [83]. Here, CD274 is linked to breast cancer.