The role of vaspin in suppressing inflammation and insulin resistance was also demonstrated by a study in which administration of vaspin improved glucose tolerance and insulin sensitivity, inhibited proinflammatory cytokines, such as TNFa, resistin, and leptin, and increased levels of adiponectin and GLUT4 in the white adipose tissue of obese mice [129]. The gene discussed is SLC2A4; the disease is Insulin resistance.