It is known that the beneficial functions of CR in metabolic homeostasis and lifespan extension are due to increased insulin sensitivity and improved adipose tissue function; however, several studies place greater emphasis on the importance of adipose tissue function because even in mTORC2-knockout mice with induced insulin resistance, the beneficial functions of CR are maintained, and some long-lived mice do not show an increase in insulin sensitivity [188,189]. The gene discussed is INS; the disease is Insulin resistance.