The authors showed that the high content of IL-33 and IgE, along with its infiltration in the dermis, stimulate the production of IL-2 by MC, which activates Tregs and indicates a complex mechanism of atopic dermatitis, which includes the anti-inflammatory effect of MC, IL-33, and IgE, which are conventionally considered pro-inflammatory factors [136]. Here, IL2 is linked to atopic eczema.