KRAS and familial pancreatic carcinoma: Given the pivotal role of autophagy in PDAC pathogenesis, regulated by TRPML1 and TFEB, TRPML1 knockdown impedes PDAC cell proliferation in vitro and suppresses tumor formation and growth in vivo [27,31,32], Unlike HRAS-driven cancer, the precise anticancer mechanisms of TRPML1 inhibition are not clearly specified in KRAS-driven pancreatic cancer.