Recent insights suggest that, in addition to its conventional role in maintaining lysosomal function and balance, TRPML1 aids in communication between lysosomes and mitochondria to regulate mitochondrial calcium levels, integrates cellular stress signals with lysosomal biogenesis, modulates membrane lipid assembly to enhance oncogenic signaling, and promotes the release of extracellular ATP to support invasive cancer behavior [21,26,27,28]. Here, MCOLN1 is linked to cancer.