We used the ClueGO and Cytoscape’s CluePedia plug-ins to investigate the enriched pathways and protein interaction network between eight key genes involved in the Wnt/β-catenin pathway (CER1, FRAT1, FSTL1, RPSA, BMP2, RPL18A, RPL19, RPS12) significantly associated with mortality and disease progression in patients with glioma. The gene discussed is RPSA; the disease is central nervous system cancer.