Our analysis detected for the first time the elevation of the keratins K1C10 and K22E in COVID-19 patients with pre-existing comorbidities, while previous studies found an enrichment of keratinization, increased plasma levels of KRT19 in COVID-19 patients, and association of KRT7 with COVID-19 severity [38,39,40]. The gene discussed is KRT7; the disease is COVID-19.