Literally, patatin-like phospholipase domain-containing protein 3(PNPLA3),atransmembrane 6 superfamily member 2 (TM6SF2), glucokinase regulatory protein (GCKR), and membrane-boundO-acyltransferase 7(MBOAT7)are major genes associated with NAFLD. Here, GCKR is linked to metabolic dysfunction-associated steatotic liver disease.