The authors, having studied a sample of 1106 patients with BC and 1180 controls (Shanghai population of China), showed that the SNP rs6259 (Asp327Asn) SHBG had the most pronounced associations with BC in women with low BMI (OR = 0.46) as well as in individuals with an ER-positive form of the disease (OR = 0.64), whereas in patients with ER-negative disorder, this polymorphism was not associated with the BC risk [145]. Here, SHBG is linked to breast cancer.