The data obtained in the future (after confirmation in other studies) can be used to form a high-risk group for BC among obese women (with the SHBG-reducing allele C rs10454142 PPP1R21), and in this group of women, weight loss (BMI) can be recommended as an effective preventive measure aimed at reducing the BC risk since, according to our data, among individuals without obesity, SHBG-reducing SNP rs10454142 PPP1R21 was no longer associated with an increased risk of BC. The gene discussed is SHBG; the disease is obesity due to melanocortin 4 receptor deficiency.