In this section of the work, we evaluate the possible functional value of rs10454142 PPP1R21 and 10 strongly coupled SNPs (r ≥ 0.80) in the following: (a) the liver (the main organ of SHBG synthesis in the organism [16]), (b) adipose tissue (the obesity-dependent association of the rs10454142 PPP1R21 with BC we found in this work), and (c) in general in the organism. This evidence concerns the gene PPP1R21 and obesity due to melanocortin 4 receptor deficiency.