It has been experimentally proven that in the absence of stonin 1, neuron-glial antigen 2 accumulates on the cell surface, which leads to “activation” of cell migration, and conversely, the presence of stonin 1 improves internalization of neuron-glial antigen 2 (due to stonin 1-mediated endocytosis of this oncogenic proteoglycan), which disrupts the “work” of the system’s local adhesion and leads to a decrease in the level of cellular signaling of this system and a decrease in cell mobility (including tumor cells) [95]. This evidence concerns the gene STON1 and neoplasm.