Using the MR method by Dimou et al., a genetic link was found between a high level of SHBG and a low risk of BC in general (OR = 0.94) and an ER-positive variant of the tumor (OR = 0.92) but a high risk of an ER-negative form of the disease (OR = 1.09) in postmenopausal women [21]. This evidence concerns the gene SHBG and breast cancer.