Interestingly, in our earlier study (the same sample of patients/controls was studied), the modifying effect of obesity on the correlation of the functionally significant SNPs of matrix metalloproteinases genes with BC risk was shown; at that, in obese women, c.836 A > G MMP9 (rs17576) and c.1721 C > G MMP9 (rs2250889) were disease-associated, and in non-obese women, c.-1306 C > T MMP2 (rs243865) and c.1331-163 G > A MMP9 (rs3787268) were BC-linked [39]. The gene discussed is MMP2; the disease is obesity due to melanocortin 4 receptor deficiency.