From the literature reviews, we can see that NECTIN2 has inflammatory roles in the brain [80], TOMM40 causes neuro-inflammation and Alzheimer’s disease [81] and APOC4-APOC2 may affect the TOMM40-APOE-APOC2 axis, related to Alzheimer’s disease [82]. This evidence concerns the gene NECTIN2 and early-onset autosomal dominant Alzheimer disease.