From the literature reviews, we can see that NECTIN2 has inflammatory roles in the brain [80], TOMM40 causes neuro-inflammation and Alzheimer’s disease [81] and APOC4-APOC2 may affect the TOMM40-APOE-APOC2 axis, related to Alzheimer’s disease [82]. The gene discussed is TOMM40; the disease is Alzheimer disease.