CRP demonstrated a significant causal association with AMD based on analyses using the IVW method (MR OR = 1.13; 95% confidence interval (CI), 1.02–1.24; p = 0.014), weighted-median method (MR OR = 1.18; 95% CI, 1.00–1.38; p = 0.044), and MR–Egger (MR OR = 1.31; 95% CI, 1.13–1.52; p < 0.001) (Figure 2). The gene discussed is CRP; the disease is age-related macular degeneration.