The reduced expression of GLT1/EAAT2 and GLAST/EEAT1 proteins (coded by Solute Carrier Family 1 Member 2 (SLC1A2) and SLC1A3 genes, respectively) in astrocytes leads to glutamate-mediated excitotoxicity that causes neuronal damage, a condition that has been observed in the brain during aging, various pathologies such as traumatic brain injury, and numerous neurodegenerative diseases [6,7,77]. The gene discussed is SLC1A2; the disease is neurodegenerative disease.