The involvement of other phosphatases, such as protein phosphatase 1 (PP1), protein phosphatase 5 (PP5), and phosphatase and tensin homolog deleted on chromosome 10 (PTEN), although less pronounced than PP2A, still contributes to the complex regulation of tau phosphorylation and has been observed to be altered in AD as well. The gene discussed is PTPA; the disease is Alzheimer disease.