Intracoronary administration of the Doxy, ML-7, and L-NAME mixture during ischemia led to a decrease in MMP-2 (p = 0.0134), MMP-9 (p = 0.017), MLC1 (p = 0.003), and BNP-26 (p = 0.002) concentrations in the blood as compared to the MI. The gene discussed is MLC1; the disease is ischemia.