In a cohort of human non-small cell lung cancer (NSCLC) specimens, HDAC10 (class II) expression positively correlated with PD-L1, with high-level expression of HDAC10 indicating dismal patient prognosis [51], while in hepatocellular carcinoma samples, increased HDAC9 (class II) and HDAC2 (class I) expression showed a positive correlation with PD-L1 levels [52]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.