By analyzing the scRNA-seq and TCR-seq data from five kinds of cancer, including NSCLC, basal cell carcinoma, breast cancer, renal cell cancer and squamous cell carcinoma, Liu et al. revealed that the CD8+CXCL13+ T cells had correlated with response to ICB and the counts of these cells increased after ICB [41]. The gene discussed is CD8A; the disease is cancer.