Moxifloxacin inhibited nitric oxide synthesis and the cytokine-induced activation of NF-κB and MAP kinases in the A549 alveolar epithelial cell line [104]; meanwhile, the expression of inflammatory mediators (IL-6, IL-8) that are dependent on NF-κB- and MAP-kinase and induced by TNF-α was inhibited in cystic fibrosis epithelial cells [106]. This evidence concerns the gene NFKB1 and cystic fibrosis.