USP7 downregulation resulted in radioresistance in a p53 wild-type (wt) human colon carcinoma xenograft model and radiosensitization in p53 wt laryngeal squamous cell carcinoma cells, which also showed an endogenous increase in USP7 expression after irradiation [34,35]. This evidence concerns the gene TP53 and laryngeal squamous cell carcinoma.