Although knock-out of FBXW11 did not completely block the degradation of IL-17RA, which was attributed to FBXW1A compensation in the A549 cell line but not in the Ishikawa cell line [76], we demonstrated an inverse correlation between FBXW11 mRNA levels and IL-17RA protein levels in 12 human cell lines, including immortalized normal cell lines and cancer cell lines (Figure 5A–D). The gene discussed is IL17RA; the disease is cancer.