Kawasaki et al. showed that patients with IgAV who had higher serum S100A8/A9 levels also had more severe renal disease and suggested that serum S100A8/A9 levels may be associated with the severity of renal disease in patients with IgAV nephritis (IgAVN), but also noticed that further studies are required [14]. The gene discussed is S100A8; the disease is kidney disorder.