S100A8 and Kawasaki disease: Patients with Kawasaki disease, with the active disease, had higher levels of serum S100A8/A9 than those in remission and although it had no predictive values of intravenous immunoglobulin response, it was shown to be a good marker of disease activity, and persistently elevated levels in serum were associated with a higher risk of developing coronary artery aneurisms [20,21].