Different types of inflammation may induce upregulation of S100A8/A9 production, not only immune system related conditions including autoimmune diseases and hypersensitivity reactions, but also infections, metabolic inflammation such as gout, diabetes, or obesity, or inflammatory processes in degenerative diseases, for example, osteoarthritis [4,5,6,7]. Here, S100A8 is linked to obesity due to melanocortin 4 receptor deficiency.