Different types of inflammation may induce upregulation of S100A8/A9 production, not only immune system related conditions including autoimmune diseases and hypersensitivity reactions, but also infections, metabolic inflammation such as gout, diabetes, or obesity, or inflammatory processes in degenerative diseases, for example, osteoarthritis [4,5,6,7]. The gene discussed is S100A8; the disease is osteoarthritis.