Similarly, Yan et al. showed that IL-17 induced glomerular injury, proteinuria and podocyte dedifferentiation in a rat model of adriamycin nephropathy [92], and Zhang et al. demonstrated that the administration of IL-17 neutralizing antibodies reduced glomerular injury, preserved podocyte numbers and ameliorated proteinuria in an experimental model of diabetic nephropathy [93]. This evidence concerns the gene IL17A and diabetic kidney disease.