CASP8 and cancer: For instance, a variety of chemotherapy drugs such as doxorubicin and epirubicin could induce pyroptosis in breast cancer by promoting the expression of nuclear PD-L1 and GSDMC and facilitating the activation of caspase-8 [37]; thus, the induction of non-apoptotic regulated cell death, such as pyroptosis, can be considered as a new anticancer therapy since cancers are born with resistance to apoptosis.