PALB2 and breast cancer: The CanRisk Tool (BOADICEA v6) (https://canrisk.org, accessed on 27 February 2024) is a model for calculating BC and ovarian cancer risks based on family history and genotypes for PGVs in BRCA1/BRCA2, PALB2, CHEK2, ATM, BARD1, RAD51C, and RAD51D and incorporates the effects of common genetic variants (summarized as polygenic risk scores, PRS), lifestyle, hormonal and clinical characteristics, breast density, and disease histopathology.