Characteristic features in PWS including serious health concerns include compulsive skin picking, strabismus, scoliosis, osteoporosis, hypogonadism (genital hypoplasia), small hands and feet, short stature, low level of growth hormone, and other hormonal deficiencies including hypothyroidism and central adrenal insufficiency [62,64]. This evidence concerns the gene GH1 and Prader-Willi syndrome.