The premutation occurs when the repeats are in the range of 55 to 200 and can result in either early menopause (fragile X-associated primary ovarian insufficiency), fragile X-associated tremor ataxia syndrome (FXTAS, which is a progressive neurodegenerative disorder occurring later in life), or fragile X-associated neuropsychiatric disorder (FXAND). This evidence concerns the gene PSMB5 and fragile X-associated tremor/ataxia syndrome.