Ellagic acid suppressed de novo lipogenesis by inhibiting the expression of sterol regulatory element-binding protein-1(SREBP-1)/fatty acid synthase (FASN) cascade and reducing steatosis in human hepatoma cell line through activation of AKT/mTORC1 (protein kinase B/mammalian target of rapamycin) in the liver [212]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.