NFKB1 and Alzheimer disease: Furthermore, it has been shown by Li et al. that an oral treatment of TGN-Res@SeNPs nanocomposites effectively improved AD by inhibiting Aβ aggregation and deposition in the hippocampus, decreasing ROS and enhancing antioxidant enzyme activities, leading to a downregulation of the neuroinflammatory cascade, particularly the NFκB/MAPK/Akt signaling pathway, and ultimately alleviating gut microbiota disorders by decreasing proinflammatory gut pathogens such as Alistipes, Helicobacter, Rikenella, Desulfovibrio and Faecalibaculum in cells and rodents [222].