NCOA4 and Cognitive impairment: Ginkgolide B, a terpenoid found in Ginkgo biloba, by targeting the Nrf2/GPX4 signaling pathway, has been shown to ameliorate AD-related cognitive impairment in senescence mice by decreasing the iron content in the brain, transferrin receptor 1 (TFR1) and nuclear receptor coactivator 4 (NCOA4) expression, and by increasing ferritin heavy chain (FTH1) expression [290].