IL6 and colitis: In addition, other authors also demonstrated that a new polysaccharide isolated from HE (HEP10) suppressed the LPS/DSS-induced production of iNOS and COX-2 and proinflammatory mediators such as TNF-α, IL-6 and IL-1β, as well as NLRP3 inflammasome, in rodent models of colitis and in macrophages.