Interestingly, the synergistic combination of HE and CV at a dose of 200 mg/kg orally for 28 days upregulated antioxidant Nrf2/HO-1 redox signaling and increased anti-inflammatory lipoxin A4 to inhibit the neuroinflammation (NF-κB pathway) and apoptosis of dopaminergic neurons in a rodent model of PD [162] and TBI [147]. This evidence concerns the gene NFKB1 and Parkinson disease.