Interestingly, salidroside, a polyphenol contained in Rhodiola Rosea L., effectively reduced intracellular Fe2+ levels, attenuating lipid peroxidation and mitochondrial damage and enhancing the expression of GPX4 and SLC7A11 by targeting Nrf2/HO1 signaling to block neuronal ferroptosis in hippocampal cells and Aβ1-42-induced AD mice [291]. Here, GPX4 is linked to Alzheimer disease.