In the case of the five Italian legume honeys, although supported only by in vitro studies, it is possible to hypothesize that when gallic acid and HMF are concurrently present, honey could represent a potentially important natural source, coupled, eventually, with conventional drugs, in the treatment of neurodegenerative diseases such as Alzheimer and Parkinson due to its inhibitory action against AChE and tyrosinase. This evidence concerns the gene ACHE and neurodegenerative disease.