MMP12 and neoplasm: One cluster corresponded to myeloid-derived suppressor cells (MDSCs) (Ly6C+, Itgam+, Cxcl3+, Il1a+, Il1b+), two corresponded to M0-like macrophages (MHC II+ type and Cx3cr1+ type), one corresponded to M1-like tumor-associated macrophage (TAM) (IL1b+, Cxcl3+, Il1a+, Mmp12+), two corresponded to M2-like TAMs (Arg1+ TAM1 type and Cd206+IL10+ TAM2 type), and the final cluster corresponded to cycling macrophages (Pclaf+, Tubb5+) (Figure 6B and Supplementary Figure S6).