HDAC6 and B-cell chronic lymphocytic leukemia: The detachment of HDAC6 from this compound also leads to excessive acetylation and suppression of the chaperone activity of hsp90, resulting in the reduction of CLL-related, growth-promoting, and survival-promoting hsp90 [96] client proteins, including ZAP70, c-RAF, AKT, and finally HDAC6 itself [97,98,99,100].