Several aspects of CML have been linked to OS, including dominance of one or more malignant clones or subclones, DNA alteration and defective DNA repair, antiapoptotic effect of p210 protein, and genomic instability in hematopoietic stem cells associated with bcr-abl oncoprotein [20,21,22]. The gene discussed is EVPL; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.