In the case of the positive associations of fasting plasma insulin and HOMA-IR with SOD enzyme activity observed in this study, the results are in line with the previous report on a cohort of children from Iran with normal weight or obesity, where the gene expression of Mn-SOD was founded in a positive correlation with serum insulin levels and HOMA-IR [42]. The gene discussed is SOD1; the disease is obesity due to melanocortin 4 receptor deficiency.