In the child population, while the total antioxidant capacity and the antioxidant enzyme activity of CAT and GPx have been reported to be significantly reduced in children with overweight and obesity in comparison with normal-weight children [13,17,18], the enzymatic activity of SOD has been observed elevated [19,20,21] or without difference [22]. The gene discussed is SOD1; the disease is obesity due to melanocortin 4 receptor deficiency.