Protein arginine methyltransferase 1 (PRMT1), which is the primary enzyme responsible for the asymmetric arginine methylation of histone proteins, plays a pronounced function in renal fibroblast activation and the development of renal fibrosis by activating the TGF-β/Smad3 signaling pathway [198]. This evidence concerns the gene TGFB1 and renal fibrosis.