NF-κB pathway activation results in the translocation of effector molecules into the nucleus and elevated expression of proinflammatory genes, including TNF-α, MCP-1, IL-6, and TGF-β1 [13], contributing to apoptosis and necrosis in cells and tissue fibrosis, which accelerates the development of DKD [133]. The gene discussed is TGFB1; the disease is diabetic kidney disease.