Inhibiting the protein levels of TNF-α, IL-6, IL-1β, cleaved IL-1β, NLRP3, and cleaved caspase-1 in the APMK/SIRT1/NF-κB pathway effectively blocks oxidative stress and inflammatory responses associated with pyroptosis, thereby preventing the progression of DKD [183]. The gene discussed is TNF; the disease is diabetic kidney disease.