Additionally, hyperglycemia can cause damage to the ultrastructure of renal tissue by inhibiting the level of phosphorylated-AKT (P-AKT), and increasing the levels of P-GSK-3β, B-cell lymphoma/leukemia 2-associated X protein (BAX), and cleaved-caspase-3 in STZ-diabetic rats [156]. This evidence concerns the gene AKT1 and Hyperglycemia.