The insulin resistance in HepG2 cells can be improved by elevating the expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2), superoxide dismutase (SOD), NADPH quinone oxidoreductase (NQO1), heme oxygenase-1 (HO-1), and glutathione peroxidase (GSH-Px) [21]. This evidence concerns the gene HMOX1 and Insulin resistance.