The potential molecular mechanisms underlying AFB1-induced inflammatory responses and immunotoxicity may involve various pathways, such as the protein kinase C (PKC), AHR, NF-κB, toll-like receptor 4 (TLR4), NRLP3, MAPK, and receptor-interacting serine/threonine-specific protein kinase 1 (RIPK1) pathways [1,38,113,114,115]. This evidence concerns the gene TLR4 and immune system toxicity.