Left panel: In Aβ1–42-infused Prdx6 transgenic mice, the overexpression of Prdx6 could increase iPLA2 activity and oxidative stress in astrocytes, and increase the β-secretase activity and the expression of APP, BACE1, resulting in increased Aβ aggregation, then accelerate the development of AD. The gene discussed is PRDX6; the disease is Alzheimer disease.