In the brains of AD patients, Prdx6 was significantly increased in astrocytes in both white and gray matter in the midfrontal cortex, cingulate, hippocampus, and amygdala, and astrocytes with a high expression of Prdx6 participated in the detoxification of diffuse plaque [43] (Table 1). The gene discussed is PRDX6; the disease is Alzheimer disease.