PRDX6 and Alzheimer disease: The upregulation of Prdx6 attenuates Aβ pathology and may contribute to AD treatment in the hemizygous knock-in of Prdx6 in APPswe/PS1dE9 AD transgenic mice, which promotes the selective induction and penetration of astrocytes in Aβ plaques and promotes microglia phagocytic activation [6].