In this study, marked increments in the gene expressions of pro-inflammatory cytokines (i.e., IL1β, IL6, and TNF-α) and reductions in the gene expressions of anti-inflammatory cytokines (i.e., IL10) were observed in the CPC50 group, which indicated that reinforcement in antioxidant capacity (including enzyme activities and gene expressions) by CPC replacing 50% fishmeal could be conductive to weakening intestinal inflammation induced by an increase in plant protein sources. Here, IL1B is linked to inflammatory response.