The limited expression of HMGCR and DHCR24 and lower cholesterol content in our Ts2 mouse model and ApoE4 astrocytes [29] imply meaningful issues about the pharmacological treatment of AD-like neurodegeneration with the use of lipid lowering agents, in particular statins which are HMGCR inhibitors. The gene discussed is DHCR24; the disease is Alzheimer disease.