Essential fast myosin light chains (MYL-3/MLC-3) belong to key contractile proteins like Myosin heavy chains (MyHCs), troponins (TnTs 1-3))/tropomyosins (TPM1-3), and α-actins (ACTA1) from skeletal muscle and are considered hallmarks of fiber type transition in the muscle aging process (sarcopenia) that leads to atrophy and frailty [58]. This evidence concerns the gene MYL3 and sarcopenia.