anti-cardiomegaly, anti-cholestatic, anti-fibrotic, anti-obesity, anti-osteoporotic, antineoplastichTERT expression decreaseDNA binding, c-Myc, and Sp1 protein reductionhTERT post-transcriptional and translational inhibitiontelomerase activity decrease. The gene discussed is SP1; the disease is obesity due to melanocortin 4 receptor deficiency.