INS and cancer: anti-cancer, growth inhibition, apoptosis activation, anti-proliferation, cell differentiation, cancer cells sensitization (their easier cellular intake)telomerase activity, time-to-treatment, overall survival, pro-inflammatory cytokine, and calcemic complications decreasesmineralization, insulin secretion, cell maturation, and blood pressure regulationVDR-RXR binds to VDRE in DNA, causing hTERT suppressiontumor necrosis factor-α protein (TNF-α) elevationendogenous nitric oxide generationG1-G0 cell cycle blockagecyclin-dependent kinase inhibitors increaseleukemia development arrest