CREB1 and major depressive disorder: Overall, the results showed that the use of BM (alone or combined with other compounds) could increase Cyclic AMP response element-binding protein (CREB) phosphorylation and reduce Nuclear Factor-κB (NF-κB) phosphorylation, improve emotional function, cognitive function, cognitive flexibility, anhedonia, hyperactivity, executive functioning, interpersonal problems, sleep routine, depression, attention-deficit, learning problems, learning rate, memory retention, memory accuracy, impulsivity, and psychiatric problems.