Ginger supplementation (500 mg of ginger, 3 × day) in a study with 100 women with PCOS showed significant decreases in FSH (follicle-stimulating hormone) and LH (Luteinizing hormone) levels compared to the placebo, while a cinnamon supplementation of 500 mg 3 × day lowered testosterone levels [31]. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.