Although uterine artery Doppler scans may improve the screening performance provided by sFlt-1/PlGF ratio at 24 weeks, mainly improving the prediction of severe preeclampsia with its specific complications, we consider it to be particularly useful in many healthcare systems affected by limited resources, where determining the sFlt-1/PlGF ratio values in all pregnancies considered to be high-risk can be unfeasible from a financial point of view, representing a financial burden, a situation also exposed in the study published by Oancea et al. [41]. The gene discussed is PGF; the disease is preeclampsia.