As far as the biochemical markers are concerned, two serum proteins—soluble fms-like tyrosine kinase 1 (sFlt-1), an antiangiogenic protein, and placental growth factor (PlGF), a proangiogenic protein—have displayed increased performance compared to the traditional medical history and clinical factors in predicting HDPs, mainly preeclampsia and some of its related complications, such as fetal growth restriction (FGR), antepartum fetal demise or preterm delivery [9]. The gene discussed is PGF; the disease is preeclampsia.