The algorithm comprising the combination of a sFlt-1/PlGF cutoff of 102.74, with a mean uterine PI cutoff of 1.44 and a mean uterine RI cutoff of 0.69 enhances the prediction accuracy of severe, early-onset preeclampsia complicated by FGR and acute fetal distress with a CPR of <one, compared to the biochemical markers or uterine Doppler parameters used alone. The gene discussed is PGF; the disease is preeclampsia.