sFlt-1 is an important regulatory marker of angiogenesis in various tissues throughout the body [10,11], but its overexpression, in combination with the underexpression of PlGF, typically imbalances normal placental angiogenesis, thus creating the conditions for later occurrences of HDPs during pregnancy, especially de novo preeclampsia [12,13]. The gene discussed is PGF; the disease is preeclampsia.