More recently, Cyp1b1-KO mice on a pure C57BL/6J background were used to explore the effects of Cyp1b1 on hypertension, revealing decreased TM collagen, elevated TM endothelial cell counts, and elevated collagen lesion scores compared to controls; these scores were observed to increase progressively with age [61]. Here, CYP1B1 is linked to hypertensive disorder.