Melatonin synthesis in the eye, acting as a CYP1B1 inhibitor, and its modulation of retinal functions, such as dopamine synthesis, photoreceptor activity, and IOP regulation, suggest a potential link between CYP1B1-mediated retinoid metabolism, melatonin signaling, and glaucoma [52,53]. This evidence concerns the gene CYP1B1 and glaucoma.